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Categories: Peptides & Proteins / Proteins

Product name			Brain Natriuretic Peptide, Pro, aa77-108, Human (proBNP, prohormone brain natriuretic peptide)
Catalog No			USB-B2702-03J
Supplier’s Catalog No			B2702-03J
Supplier			US Biologicals
Source antigen			Synthetic
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			~95% (HPLC)
Form			Supplied as a lyophilized powder. Reconstitute in 0.1% acetic acid.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (HPLC)
Description			Human brain natriuretic peptide (BNP) is a secreted protein which is a member of the natriuretic peptide family. BNP is a cardiac hormone, which is synthesized as a pro-hormone (proBNP), and is proteolytically cleaved to release a biologically active fragment (BNP), and an inactive fragment (NT-proBNP) into the circulation. BNP is predominantly secreted from the cardiac ventricles in response to volume and pressure overload, and results in a number of biological activities including natriuresis, diuresis, vasorelaxation, and inhibition of the sympathetic nervous system. A high concentration of BNP in the bloodstream is indicative of heart failure. Applications: Specific methodologies have not been tested using this product. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 0.1% acetic acid and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.