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Categories: Peptides & Proteins / Proteins

Product name			JAK3, Control Peptide (Janus Kinase 3, EC 2.7.10.2, JAKL, Leukocyte Janus Kinase, LJAK)
Catalog No			USB-J0902-07
Supplier’s Catalog No			J0902-07
Supplier			US Biologicals
Source antigen			Synthetic peptide
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			95+% HPLC, Mass Spec
Form			Supplied as a white to off-white lyophilized powder.
Reactivity life			12 months
Note			For reserch purpose only
Purity			95+% HPLC, Mass Spec
Description			Synthetic (linear) peptide (GGEEEEYFELVKKKK) used as a substrate for JAK3. Janus Kinase 3 (Jak3) belongs to the Jak family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID). Applications: Analytical Tests: Peptide identity confirmed by MALDI-ToF MS and Amino Acid analysis. Kinase Assay: Substrate for JAK3, active. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.