SPARC (119-122) (mouse)
Catalog No : USB-S5370-25
564.38€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | SPARC (119-122) (mouse) | ||
|---|---|---|---|
| Catalog No | USB-S5370-25 | ||
| Supplier’s Catalog No | S5370-25 | ||
| Supplier | US Biologicals | ||
| Source antigen | Synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | Mouse, | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | 95+% HPLC, Mass Spec | ||
| Form | Supplied as a white to off-white lyophilized powder. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | 95+% HPLC, Mass Spec | ||
| Description | Osteonectin is an acidic, noncollagenous glycoprotein (Mr=29,000) originally isolated from fetal and adult bovine bone matrix (1-5). In vitro bovine bone osteonectin binds type I collagen, calcium (Kd=3x10(-7)M) and hydroxyapatite (Kd=8x10(-8)M) and has been shown to be a potent inhibitor of hydroxyapatite seeded crystal growth (6). In this context it has been suggested that osteonectin may play an important role in the regulation of bone metabolism by binding hydroxyapatite to collagen. Recently, proteins homologous to osteonectin nave been identified in a number of cell types, most of which are associated with extracellular matrix production (7). The amino acid sequence (from cDNA sequences) of one of these proteins, human placental SPARC, is identical to human bone osteonectin. Osteonectin has also been identified as an alpha granule component of human platelets and is secreted during platelet activation. A small portion of the secreted osteonectin is expressed on the platelet cell surface in an activation-dependent manner (8). Purified platelet osteonectin is a single chain molecule which exhibits a slightly larger apparent molcular weight than that of osteonectin derived from bone (8). The NH2-terminal sequences of platelet and bone-derived osteonectin are identical, but the two proteins differ with regard to the extent of glycosylation (8-10). Human platelet osteonectin is isolated from thrombin-activated platelets as described by Kelm, et al. (8). Bovine bone osteonection is isolated from demineralized bone by the method of Romberg, et al. (2). Sequence (linear): Lys-Gly-His-Lys Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | ||
Product Details
© 2020 Imugex All Rights Reserved