Sarafotoxin S6b (Atractaspis engaddensis) (Sarafotoxin B)
Catalog No : USB-S0170-01A
564.38€
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| Product name | Sarafotoxin S6b (Atractaspis engaddensis) (Sarafotoxin B) | ||
|---|---|---|---|
| Catalog No | USB-S0170-01A | ||
| Supplier’s Catalog No | S0170-01A | ||
| Supplier | US Biologicals | ||
| Source antigen | Synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 2564 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | 95+% HPLC, Mass Spec | ||
| Form | Supplied as a white to off-white lyophilized powder. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | 95+% HPLC, Mass Spec | ||
| Description | Sarafotoxins (SRTXs) are group of toxins present in a venom of Atractaspis engaddensis, and in clinical trials cause similar symptoms to patients diagnosed with acute giardiasis.[1] Together with endothelins (ETs), they form a homogenous family of strong vasoconstrictor isopeptides. Among them, few slightly different substances can be named, as SRTX-a, SRTX-b, SRTX-c, which were initially derived from Atractaspis engaddensis. Each contains twenty-one amino acid residues that spontaneously fold into a defined tertiary structure with two interchain-cysteine linkages (disulfide bonds) and a long hydrophobic tail.[2] There are also other compounds, however, they are mostly derivations of previously mentioned ones. The main differences in the family of endothelin and sarafotoxins appear at N-terminal of peptides, as C-terminal in all of them is almost the same.[3] CAS Number: 116303-65-2 Molecular Formula: C110H159N27O34S5 Molecular Weight: 2564 Appearance: White lyophilized solid Purity (HPLC): ~95% Sequence: Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile--Trp (CSCKDMTDKECLYFCHQDVIW) Modifications: Disulfide bridge between: 1-15, 3-11 Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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