Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Cyclic GMP (cGMP) Protein Kinase Substrate [Arg-Lys-Arg-Ser-Arg-Lys-Glu]
Catalog No			USB-C8451-07C
Supplier’s Catalog No			C8451-07C
Supplier			US Biologicals
Source antigen			Synthetic peptide
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			95+% HPLC, Mass Spec
Form			Supplied as a white to off-white lyophilized powder.
Reactivity life			12 months
Note			For reserch purpose only
Purity			95+% HPLC, Mass Spec
Description			Sequence (linear): Arg-Lys-Arg-Ser-Arg-Lys-Glu Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG). Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.