Liver Specific Transporter, Human, Control Peptide (LST-1)
Catalog No : USB-L3176-05
417.25€
0.00€
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| Product name | Liver Specific Transporter, Human, Control Peptide (LST-1) | ||
|---|---|---|---|
| Catalog No | USB-L3176-05 | ||
| Supplier’s Catalog No | L3176-05 | ||
| Supplier | US Biologicals | ||
| Source antigen | Synthetic | ||
| Reactivity | |||
| Cross reactivity | Human, | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.5. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Most recently, a novel liver-specific OAT, LST-1, has been cloned from human liver. It has also been detected in mouse and rat liver. No significant expression of LST-1 was detected in other tissues. Human LST-1 (691 aa, 12 TM) shares 42% homology with human OATP, rat oatp1-3, and OATK-1, and 35% with PGT. Phylogenetic analyses places LST-1 between oatp and PGT. LST-1 has wide substrate specificity (taurocholate, conjugated steroids, PGE2, Thromboxane B2, leukotrienes, and T3). Therefore, LST-1 may be more important for clearance of bile acids and organic anions in liver. Synthetic peptide corresponding to 17aa sequence near the C-terminus of human LST-1 Recognizes human Liver Specific Transporter. No significant sequence homology is detected with other OATP1-3, OATP or PGT. Applications: Suitable for use in Antibody Blocking and ELISA. Not suitable for Western Blot. Other applications not tested. Recommended Dilutions: Antibody Blocking: 5-10ug/ug per 1ug of of affinity purified antibody (L3176-06) or 1ul of serum (L3176-07). ELISA: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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