RIP3, Blocking Peptide (Receptor Interacting Protein 3)
Catalog No : USB-R2031-74P
367.83€
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| Product name | RIP3, Blocking Peptide (Receptor Interacting Protein 3) | ||
|---|---|---|---|
| Catalog No | USB-R2031-74P | ||
| Supplier’s Catalog No | R2031-74P | ||
| Supplier | US Biologicals | ||
| Source antigen | Synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | Purified 60-70% | ||
| Form | Supplied as a lyophilized powder. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified 60-70% | ||
| Description | Peptide (AQFGRGRGWQPFHK) corresponding to amino acids 473 to 486 of murine RIP3 (3). Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 (1–3). RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues (2,3). SOURCE: Rabbit anti-RIP3 polyclonal antibody was raised against a peptide (AQFGRGRGWQPFHK) corresponding to amino acids 473 to 486 of murine RIP3 (3). Applications: Suitable for use in ELISA, Western Blotting. Other applications not tested. Positive Control: 3T3 cell lysate Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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