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Categories: Peptides & Proteins / Proteins

Product name			Apaf-1, NT, Blocking Peptide (Apoptosis Protease Activating Factor-1)
Catalog No			USB-A2298-65P
Supplier’s Catalog No			A2298-65P
Supplier			US Biologicals
Source antigen			Synthetic peptide
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Purified
Purity			Purified 60-70%
Form			Supplied as a lyophilized powder.
Reactivity life			12 months
Note			For reserch purpose only
Purity			Purified 60-70%
Description			Peptide corresponding to amino acids 12 to 28 of human Apaf1 (1). The sequences of the immunogenic peptide are identical between human and mouse (1,2) Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 is ubiquitously expressed in human tissues (1). See corresponding antibody A2298-65