Ilomastat, Liquid (GM6001, MMP Inhibitor, Galardin)
Catalog No : USB-I5500
272.42€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Ilomastat, Liquid (GM6001, MMP Inhibitor, Galardin) | ||
|---|---|---|---|
| Catalog No | USB-I5500 | ||
| Supplier’s Catalog No | I5500 | ||
| Supplier | US Biologicals | ||
| Source antigen | |||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 388.47 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | |||
| Purity | ≥ 97% by HPLC | ||
| Form | Supplied as a liquid in DMSO. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥ 97% by HPLC | ||
| Description | GM6001 MMP Inhibitor (Ilomastat) is a potent inhibitor of collagenase. Broad spectrum inhibitor of matrix metalloproteases (MMPs) with Ki factor in nM range. Widely used to inhibit MMPs in vitro experiments and in animal models. Nomenclature: N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide (2R)-N'-hydroxy-N-[(2S)-3-(5H-indol-3-yl)-1-methylamino-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide Reported Ki values are as follows (see Galardy Ref): Human MMP-1 (Fibroblast collagenase): 0.4nM Human MMP-3 (Stromelysin): 27nM Human MMP-2 (72kD gelatinase): 0.5nM Human MMP-8 (Neutrophil collagenase):0.1nM Human MMP-9 (92kD gelatinase): 0.2nM Applications: Suitable for use in Cell Culture. Recommended Dilutions: Cell Culture: 10-25uM (1mg/ml in DMSO = 2.57mM) Recommended Dilution Buffer: 50mM Tris pH7.5, 150mM NaCl, 20mM CaCl2-2H2O. Recommended Dilution Concentration: It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Relative concentrations of GM6001 in aqueous solutions may be determined by measuring the absorbance of the solution at 280nm. Quality Control: H-NMR Spectrum: Conforms Mass Spectrum: 389 [M+1] Thin Layer Chromatography (ethylacetate:methanol = 6:1): Single spot Storage and Stability: For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
Product Details
© 2020 Imugex All Rights Reserved