Apolipoprotein E, Recombinant, Rabbit, aa19-311, His-Tag (APOE)
Catalog No : USB-370528
506.91€
0.00€
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| Product name | Apolipoprotein E, Recombinant, Rabbit, aa19-311, His-Tag (APOE) | ||
|---|---|---|---|
| Catalog No | USB-370528 | ||
| Supplier’s Catalog No | 370528 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | ~85% (SDS-PAGE) | ||
| Form | Supplied as a liquid Tris, 50% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~85% (SDS-PAGE) | ||
| Description | Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Source: Recombinant protein corresponding to aa19-311 from rabbit APOE, fused to His-Tag at N-terminal and Myc-Tag at C-terminal, expressed in E. coli. AA Sequence: QT EQEVEVPEQA RWKAGQPWEL ALGRFWDYLR WVQSLSDQVQ EELLSSQVTQ ELTMLMEETM KEVKAYKSEL EEQLSPMAQE HRARLSKELQ VAGALEADME DVCNRLAQYR GEAQAMLGQS TEELARAFSS HLRKLRKRLL RDAEDLQKRM AVYGAGAREG AERGVSAVRE RLGSRLERGR LRVATVGTLA GRPLRERAQA WGERLRGHLE EVGSRARDRL NEVREQVEEV RVKVEEQAPQ MRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKLQAAMPS KAPAAAPIEN Q Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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