Apolipoprotein A-1, Recombinant, Human (Apo-AI, ApoA-I, APOA1)
Catalog No : USB-352674
472.43€
0.00€
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| Product name | Apolipoprotein A-1, Recombinant, Human (Apo-AI, ApoA-I, APOA1) | ||
|---|---|---|---|
| Catalog No | USB-352674 | ||
| Supplier’s Catalog No | 352674 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 28.2 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~97% (RP-HPLC, SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in PBS, pH 7.0. No preservative added. Reconstitute with sterile ddH2O to 0.1mg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~97% (RP-HPLC, SDS-PAGE) | ||
| Description | Apolipoprotein A-1 (APOA1) is a human protein with a specific role in lipid metabolism being the main protein component of HDL in the plasma. APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Furthermore, APOA1 is a co-factor for LCAT, which is responsible for the formation of most plasma cholesteryl esters. In addition, APOA1 activates spermatozoa motility as part of the SPAP complex. The APOA1 gene is strongly linked with two other apolipoprotein genes on chromosome 11. Defects in the APOA1 gene are linked to HDL deficiency including Tangier disease, and with systemic non-neuropathic amyloidosis. High levels of APOA1 are linked to the manifestation of asthma and atopy. Source: Recombinant protein corresponding to human Apolipoprotein A-1, a single, non-glycosylated polypeptide chain containing 244aa expressed in E. coli. Molecular Weight: ~28.2kD AA Sequence: MDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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