Clusterin, Recombinant, Human, aa23-449, His-Tag (CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, Clusterin, Apolipoprotein J, ApoJ)
Catalog No : USB-301193
429.90€
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| Product name | Clusterin, Recombinant, Human, aa23-449, His-Tag (CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, Clusterin, Apolipoprotein J, ApoJ) | ||
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| Catalog No | USB-301193 | ||
| Supplier’s Catalog No | 301193 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 51.1 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in 25mM Na2HPO4, 100mM sodium chloride, pH 7.5. Reconstitute with ddH2O. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80kD disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. Source: Recombinant protein corresponding to aa23-449 of human ApoJ/Clusterin, fused to His-tag at C-terminal expressed in E. coli. Molecular Weight: ~51.1kD Biological Activity: The chaperone activity of ApoJ was confirmed by its ability to bind to proteins under physical stress such as heat (e.g. Thyroglobulin) and chemical stress such as change in pH (e.g. Procathepsin K). Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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