Apolipoprotein-J (Apo-J, Clusterin, CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, , MGC24903, Clusterin)
Catalog No : USB-167754
543.69€
0.00€
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| Product name | Apolipoprotein-J (Apo-J, Clusterin, CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, , MGC24903, Clusterin) | ||
|---|---|---|---|
| Catalog No | USB-167754 | ||
| Supplier’s Catalog No | 167754 | ||
| Supplier | US Biologicals | ||
| Source antigen | Human plasma | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 7580 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (HPLC, SDS-PAGE) Endotoxin: ≤0.1ng/ug | ||
| Form | Supplied as lyophilized powder from PBS, pH 7.5. Reconstitute with 20ul sterile ddH2O to a concentration of 0.5mg/ml. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (HPLC, SDS-PAGE) Endotoxin: ≤0.1ng/ug | ||
| Description | Apoliprotein J (APO-J), also named Clusterin, is a 75-80kD disulfide-linked heterodimeric protein. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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