Ulex europaeus (UEA II)
Catalog No : USB-518886
421.85€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Ulex europaeus (UEA II) | ||
|---|---|---|---|
| Catalog No | USB-518886 | ||
| Supplier’s Catalog No | 518886 | ||
| Supplier | US Biologicals | ||
| Source antigen | Gorse | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 96 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Affinity purified | ||
| Purity | Affinity purified | ||
| Form | Supplied as a lyophilized powder. | ||
| Reactivity life | 2 years | ||
| Note | For reserch purpose only | ||
| Purity | Affinity purified | ||
| Description | Affinity purified Ulex europaeus agglutinin (UEA II) is isolated from gorse seeds and separated from crude extract. This lectin is a glycoprotein that consists of four 24,000 Da monomer subunits that require Ca2+ for binding to its ligands through carbohydrate recognition domain. It is specific for di-N-acetylchitobiose, an oligomer of GlcNAc. The monosaccharide GlcNAc is not an inhibitor of the lectin activity. UEA II has no mitogenic activity and agglutinates type O erythrocytes with greater interest than type A3 erythrocytes. Addition of EDTA eliminates agglutinating activity. Agglutinating activity can be recovered with the addition of calcium.UEA II is a potent inhibitor of the lectin complement pathway following endothelial oxidative stress. The molecular mechanism of UEA II-induced inhibition of the lectin complement pathway appears to be through competition for a common binding site on the endothelial cell and not at the level of mannose-binding lectin (MBL) inhibition. See other UEA II conjugates. Source: Gorse Blood Specificity: Non-specific Sugar Specificity: Oligomers of beta(1,4) - linked N-Acetylglucosamine Inhibitory Carbohydrate: GlcNAc beta(1,4) GlcNAc Divalent Ions: Ca++, Mn++, Zn++ Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
Product Details
© 2020 Imugex All Rights Reserved