Sambucus nigra (SNA/EBL I+II)
Catalog No : USB-518735
400.01€
0.00€
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| Product name | Sambucus nigra (SNA/EBL I+II) | ||
|---|---|---|---|
| Catalog No | USB-518735 | ||
| Supplier’s Catalog No | 518735 | ||
| Supplier | US Biologicals | ||
| Source antigen | Elderberry | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 140 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | |||
| Purity | Semi-Pure | ||
| Form | Supplied as a lyophilized powder. | ||
| Reactivity life | 2 years | ||
| Note | For reserch purpose only | ||
| Purity | Semi-Pure | ||
| Description | Fractionated Sambucus nigra lectin (EBL I+II, also known as SNA) is is composed of two ricin-related lectins. EBL I+II is a tetrameric glycoprotein with a recognition of the Neu5Ac(alpha2-6)Gal or GalNAc linkage in glycoconjugates. EBL I+II is not blood group specific but it does agglutinate type A erythrocytes more strongly than either B or O cells. Trypsin treated erythrocytes react better than untreated cells. Neuraminidase treated erythrocytes react with this lectin due to the presence of terminal galactose resides. SNA has a broad specificity for both alpha- and β-linked galactose, as well as unrelated sugars such as fucose. It has been determined that the lectin does not bind to glycoproteins or glycolipids containing only terminal alpha(2,3)-linked sialic acid residues. EBL I is composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. EBL II consists only of carbohydrate-binding B-chains. EBL I+II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems independent from the catalytic activity of the A-chain, but depends on the carbohydrate binding B-chain. Source: Elderberry Sugar Specificity: Sialic Acid Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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