Galectin-1, Recombinant, Human (Beta-Galactoside-Binding Lectin L-14-I, Gal-1, 14kD Laminin-Binding Protein, HLBP14, 14kD Lectin, Galaptin, HBL, HPL, Lactose-Binding Lectin 1, Lectin Galactoside-Binding Soluble 1, Putative MAPK-Activating Protein PM12, S-Lac Lectin 1, LGALS1)
Catalog No : USB-500031
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| Product name | Galectin-1, Recombinant, Human (Beta-Galactoside-Binding Lectin L-14-I, Gal-1, 14kD Laminin-Binding Protein, HLBP14, 14kD Lectin, Galaptin, HBL, HPL, Lactose-Binding Lectin 1, Lectin Galactoside-Binding Soluble 1, Putative MAPK-Activating Protein PM12, S-Lac Lectin 1, LGALS1) | ||
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| Catalog No | USB-500031 | ||
| Supplier’s Catalog No | 500031 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 14.9 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in PBS. Reconstitute with sterile PBS to 0.1mg/ml. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumors. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kD protein. Source: Recombinant protein corresponding to human Galectin-1 expressed in E. coli. Molecular Weight: ~14.9kD Biological Activity: Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 0.53ug/mL. Endotoxin: <1EU/ug (LAL) Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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