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Categories: Peptides & Proteins / Proteins

Product name			Griffonia (Bandeiraea) simplicifolia GS II
Catalog No			USB-G8967-80
Supplier’s Catalog No			G8967-80
Supplier			US Biologicals
Source antigen
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Purified
Purity			Purified
Form
Reactivity life			12 months
Note			For reserch purpose only
Purity			Purified
Description			The seeds of Griffonia simlicifolia conain four distinct lectins, 30,000D each. Two of these lectins, referred to as GS-I and GS-II have been well characterized with regard to binding specificity and structure. GS-II is specific for terminal, non-reducing alpha or beta linked N-acetyl-D-glucosamine. This lectin is not blood group specific, unlike GS-I. GS-II is also a tetramer but it is composed of identical subunits. Each subunit has a single carbohydrate binding site for GlcNAc. GS-II is the only lectin isolated that is specific for only a terminal GIcNAc residue. The subterminal saccharide does play an important role in lectin binding. Inhibiting/Eluting Sugar: Chitin Hydrolysate or 200mM N-acetylglucosamine Activity: 5-10ug/ml will agglutinate Tk polyagglutinaable cells. Inhibitory Carbohydrate: N-acetylglucosamine Carbohydrate Specificity: Terminal a- or b- N- Acetylglucosamine. The specific linkage of N-Acetylglucosamine to the subterminal carbohydrate plays an important role in lectin binding. Note: Calcium is required for binding. 0.5mM calcium is the maximum concentration in buffer that will not form a white precipitate.