Integrin alpha5, beta1 (VLA5, Fibronectin Receptor, Very Late Antigen, CD49)
Catalog No : USB-I7661-35L
617.26€
0.00€
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| Product name | Integrin alpha5, beta1 (VLA5, Fibronectin Receptor, Very Late Antigen, CD49) | ||
|---|---|---|---|
| Catalog No | USB-I7661-35L | ||
| Supplier’s Catalog No | I7661-35L | ||
| Supplier | US Biologicals | ||
| Source antigen | Human | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Affinity Purified | ||
| Purity | ~95%. Non-reduced SDS-PAGE of 15ug on 5-15% polyacrylamide slab gel and staining with Coomassie blue shows only two main bands at 120kD (beta1 subunit) and 145kD (alpha5 subunit). A weak band at 205kD is due to dimerization of the beta 1 subunit. | ||
| Form | Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 150mM sodium chloride, 2mM MgCl2, containing 0.2% Triton X-100. No preservatives. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95%. Non-reduced SDS-PAGE of 15ug on 5-15% polyacrylamide slab gel and staining with Coomassie blue shows only two main bands at 120kD (beta1 subunit) and 145kD (alpha5 subunit). A weak band at 205kD is due to dimerization of the beta 1 subunit. | ||
| Description | The alpha5 beta1 integrin mediates cell adhesion and migration on fibronectin, a glycoprotein critical for normal vertebrate embryonic development. Indirect evidence reported to date suggests that this receptor also functions in the deposition of fibronectin matrices. Integrin alpha5/beta1 purified from smooth muscle under nondenaturing conditions by affinity chromatography on fibronectin-sepharose. Applications: Suitable for use in Western Blot, Electrophoresis and Functional Studies. In Functional Studies, liposomes containing Integrin alpha5/beta1 adhere to surfaces coated with fibronectin in an RGD-dependent fashion. Other applications have not been tested. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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