HIV-2, gp36, Recombinant (Human Immunodeficiency Virus-2)
Catalog No : USB-361718
400.01€
0.00€
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| Product name | HIV-2, gp36, Recombinant (Human Immunodeficiency Virus-2) | ||
|---|---|---|---|
| Catalog No | USB-361718 | ||
| Supplier’s Catalog No | 361718 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 17 | ||
| Storage | 4°C/-70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM Na-formate, pH 3.0. No preservative added. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | HIV-2 is a phylogenetic relative of HIV-1, which is reported to be less infectious and induce a slower progression to AIDS than HIV-1. Accordingly, the clinical outcomes and treatment approaches for HIV-1 and HIV-2 infection are different, and distinguishing between the two strains is an important diagnostic objective. Despite extensive sequence heterology between HIV-1 and HIV-2, the structures of the HIV-1 and HIV- 2 envelope proteins are similar, with HIV-2 gp36 mediating the fusogenic activity of the HIV-2 envelope, and representing the structural and functional equivalent of HIV-1 gp41. The immunodominant regions of gp41 and gp36 are, however, sufficiently distinct such that antibodies generated against HIV- 1 and HIV-2 do not cross-react significantly with their respective cognate gp41 and gp36 targets. As such recombinant gp36 is commonly used in diagnostic immunoassays to distinguish between HIV-1 and HIV-2 infections. Source: Recombinant protein corresponding to HIV-2 gp36 expressed in E. coli. Molecular Weight: ~17kD Activity: Binds HIV-2 positive serum antibodies Applications: Suitable for use in ELISA, Western Blot and Lateral Flow. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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