Anti-FANCD2 Antibody
Catalog No : IGX-62613
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. | ||
|---|---|---|---|
| Other names | FANCD2, FACD, Fanconi anemia group D2 protein, Protein FACD2 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9BXW9 | ||
| Product name | Anti-FANCD2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-62613 | ||
| Supplier’s Catalog No | IGX-62613 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human, Mouse, Rat | ||
| Applications | WB, IHC, ELISA | ||
| Recommended dilutions | WB:1:500-1:2000.IHC:1:100-1:300.ELISA:1:10000 | ||
| Molecular weight | |||
| Conjugate | Unconjugated | ||
| Immunogen | Synthetic peptide derived from human FANCD2 around the non-phosphorylation site of S222. | ||
| Specificity | This antibody detects total endogenous levels of FANCD2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||
| Formulation | Liquid | ||
| Purification | Antigen Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile).. | ||
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