Anti-CASP9 / Caspase-9 Antibody
Catalog No : IGX-59413
282.00€
201.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. | ||
|---|---|---|---|
| Other names | Caspase-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, Caspase-9 subunit p35, Caspase-9 subunit p10, CASP9, MCH6 | ||
| Cellular localization | Cytosol, Apoptosome, Mitochondrion, Nucleus, Cytoplasm, -Containing Complex | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P55211 | ||
| Product name | Anti-CASP9 / Caspase-9 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59413 | ||
| Supplier’s Catalog No | IGX-59413 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IF, Flow cyto; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200 | ||
| Recommended dilutions | WB: 1:500-1:5000, IF: 1:20-1:200 | ||
| Molecular weight | Predicted band size: 47 KDa Observed band size: 47 KDa | ||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide derived from human CASP9 | ||
| Specificity | This antibody detects total endogenous levels of CASP9 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved