Anti-HDAC6 Antibody
Catalog No : IGX-59392
282.00€
201.00€
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| Description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PMID:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PMID:10220385). Histone deacetylases act via the formation of large multiprotein complexes (PMID:10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PMID:12024216, PMID:20308065). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PMID:30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PMID:24413532). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PMID:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PMID:17846173). | ||
|---|---|---|---|
| Other names | Histone deacetylase 6, HD6, HDAC6, KIAA0901, JM21 | ||
| Cellular localization | Cytoskeleton, Nucleus, Cytoplasm, Perikaryon, Dendrite, Axon | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UBN7 | ||
| Product name | Anti-HDAC6 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59392 | ||
| Supplier’s Catalog No | IGX-59392 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC, IP; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IP:1:200-1:1000 | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:50-1:200, IP: 1:200-1:1000 | ||
| Molecular weight | |||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide derived from human HDAC6 | ||
| Specificity | This antibody detects total endogenous levels of HDAC6 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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