Anti-CD4 Antibody
Catalog No : IGX-59285
282.00€
201.00€
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| Description | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PMID:2214026, PMID:16331979, PMID:9641677, PMID:12089508). Down-regulated by HIV-1 Vpu (PMID:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PMID:7909607). | ||
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| Other names | T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4 | ||
| Cellular localization | Membrane, Single-Pass Type I Membrane | ||
| Research area | Immunology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P01730 | ||
| Product name | Anti-CD4 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-59285 | ||
| Supplier’s Catalog No | IGX-59285 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500 | ||
| Recommended dilutions | WB: 1:500-1:5000, IHC: 1:50-1:500 | ||
| Molecular weight | |||
| Conjugate | Unconjugated | ||
| Immunogen | A synthesized peptide | ||
| Specificity | This antibody detects total endogenous levels of CD4 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Monoclonal | ||
| Isotype | Rabbit IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||
| Formulation | Liquid | ||
| Purification | Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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