Anti-POGLUT1 Antibody
Catalog No : IGX-47630
262.00€
188.00€
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| Description | Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PMID:21081508, PMID:21490058, PMID:21949356, PMID:27807076, PMID:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PMID:21081508, PMID:21490058, PMID:21949356, PMID:27807076, PMID:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PMID:27807076). Notch glucosylation does not affect Notch ligand binding (PMID:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane . | ||
|---|---|---|---|
| Other names | Protein O-glucosyltransferase 1, EC 2.4.1.-, CAP10-like 46 kDa protein, hCLP46, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein, O-glucosyltransferase Rumi homolog, hRumi, Protein O-xylosyltransferase POGLUT1, EC 2.4.2.26, POGLUT1, C3orf9 CLP46 KTELC1 MDSRP | ||
| Cellular localization | Endoplasmic Reticulum Lumen | ||
| Research area | Developmental Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q8NBL1 | ||
| Product name | Anti-POGLUT1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-47630 | ||
| Supplier’s Catalog No | IGX-47630 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC | ||
| Recommended dilutions | WB: 1:1000-1:5000, IHC: 1:200-1:500 | ||
| Molecular weight | Predicted band size: 47 KDa. Observed band size: 47 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Protein O-glucosyltransferase 1 protein (132-392AA) | ||
| Specificity | POGLUT1 antibody detects endogenous level of POGLUT1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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