Anti-EXO1 / Exonuclease 1 Antibody
Catalog No : IGX-46488
262.00€
188.00€
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| Description | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. | ||
|---|---|---|---|
| Other names | Exonuclease 1, hExo1, EC 3.1.-.-, Exonuclease I, hExoI, EXO1, EXOI HEX1 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UQ84 | ||
| Product name | Anti-EXO1 / Exonuclease 1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-46488 | ||
| Supplier’s Catalog No | IGX-46488 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, WB, IHC | ||
| Recommended dilutions | WB: 1:1000-1:5000, IHC: 1:20-1:200 | ||
| Molecular weight | Predicted band size: 95 KDa. Observed band size: 95 KDa. | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Exonuclease 1 protein (301-600AA) | ||
| Specificity | EXO1 antibody detects endogenous level of EXO1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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