Anti-PAN2 Antibody
Catalog No : IGX-44199
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. | ||
|---|---|---|---|
| Other names | PAN2-PAN3 deadenylation complex catalytic subunit PAN2, EC 3.1.13.4, Inactive ubiquitin carboxyl-terminal hydrolase 52, PAB1P-dependent poly,A,-specific ribonuclease, Poly,A,-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2, PAN2, KIAA0710 USP52 | ||
| Cellular localization | Nucleus, Cytoplasm, P-Body | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q504Q3 | ||
| Product name | Anti-PAN2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44199 | ||
| Supplier’s Catalog No | IGX-44199 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit PAN2 protein (628-908AA) | ||
| Specificity | PAN2 antibody detects endogenous level of PAN2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved