Anti-AHR Antibody
Catalog No : IGX-44111
262.00€
188.00€
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| Description | Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PMID:10395741, PMID:28602820, PMID:7961644, PMID:23275542, PMID:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PMID:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PMID:7961644). Involved in cell-cycle regulation (PMID:12213388). Likely to play an important role in the development and maturation of many tissues (PMID:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PMID:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PMID:28602820). | ||
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| Other names | Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76 | ||
| Cellular localization | Cytoplasm, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P35869 | ||
| Product name | Anti-AHR Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44111 | ||
| Supplier’s Catalog No | IGX-44111 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Aryl hydrocarbon receptor protein (126-353AA) | ||
| Specificity | AHR antibody detects endogenous level of AHR protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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