Anti-NAT8 Antibody
Catalog No : IGX-44039
262.00€
188.00€
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| Description | Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PMID:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PMID:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PMID:19011241). | ||
|---|---|---|---|
| Other names | N-acetyltransferase 8, EC 2.3.1.-, Acetyltransferase 2, ATase2, Camello-like protein 1, Cysteinyl-conjugate N-acetyltransferase, CCNAT, EC 2.3.1.80, NAT8, CML1 GLA TSC501 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Single-Pass Type Ii Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UHE5 | ||
| Product name | Anti-NAT8 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-44039 | ||
| Supplier’s Catalog No | IGX-44039 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human N-acetyltransferase 8 protein (64-227AA) | ||
| Specificity | NAT8 antibody detects endogenous level of NAT8 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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