Anti-ZDHHC2 Antibody
Catalog No : IGX-44034
262.00€
188.00€
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| Description | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PMID:18508921, PMID:18296695, PMID:19144824, PMID:21343290, PMID:22034844, PMID:23793055). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses . In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors . Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons . Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PMID:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PMID:18296695, PMID:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PMID:22034844). (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. | ||
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| Other names | Palmitoyltransferase ZDHHC2, EC 2.3.1.225, Reduced expression associated with metastasis protein, Ream, Reduced expression in cancer protein, Rec, Zinc finger DHHC domain-containing protein 2, DHHC-2, Zinc finger protein 372, ZDHHC2, REAM REC ZNF372 | ||
| Cellular localization | Golgi Apparatus Membrane, Multi-Pass Membrane, Endoplasmic Reticulum Membrane, Membrane, Postsynaptic Recycling Endosome Membrane, Postsynaptic Density | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UIJ5 | ||
| Product name | Anti-ZDHHC2 Antibody | ||
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| Catalog No | IGX-44034 | ||
| Supplier’s Catalog No | IGX-44034 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Palmitoyltransferase ZDHHC2 protein (230-367AA) | ||
| Specificity | ZDHHC2 antibody detects endogenous level of ZDHHC2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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