Anti-SPIRE2 Antibody
Catalog No : IGX-43988
262.00€
188.00€
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| Description | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PMID:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport . Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PMID:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PMID:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PMID:26287480). | ||
|---|---|---|---|
| Other names | Protein spire homolog 2, Spir-2, SPIRE2, KIAA1832 SPIR2 | ||
| Cellular localization | Membrane, Peripheral Membrane, , Cytosol, Cytoskeleton, Cytoplasmic Vesicle Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q8WWL2 | ||
| Product name | Anti-SPIRE2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43988 | ||
| Supplier’s Catalog No | IGX-43988 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Protein spire homolog 2 protein (79-388AA) | ||
| Specificity | SPIRE2 antibody detects endogenous level of SPIRE2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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