Anti-C9orf72 Antibody
Catalog No : IGX-43961
262.00€
188.00€
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| Description | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PMID:27193190, PMID:27103069, PMID:27617292, PMID:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PMID:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PMID:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PMID:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PMID:27559131). Plays a role in endosomal trafficking (PMID:24549040). May be involved in regulating the maturation of phagosomes to lysosomes . Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PMID:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PMID:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PMID:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity . Isoform 1: Regulates stress granule assembly in response to cellular stress. Isoform 2: Does not play a role in regulation of stress granule assembly in response to cellular stress. | ||
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| Other names | Guanine nucleotide exchange C9orf72, C9orf72 | ||
| Cellular localization | Cell Projection, Cytoplasm, Cytoplasmic Vesicle, Endosome, Lysosome, Membrane, Nucleus, Secreted,P-Body, Stress Granule, Autophagosome, Axon, Growth Cone, Perikaryon, Dendrite, Nucleus Membrane, Peripheral Membrane | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96LT7 | ||
| Product name | Anti-C9orf72 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43961 | ||
| Supplier’s Catalog No | IGX-43961 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Guanine nucleotide exchange C9orf72 protein (138-430AA) | ||
| Specificity | C9orf72 antibody detects endogenous level of C9orf72 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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