Anti-SMG6 Antibody
Catalog No : IGX-43924
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PMID:19179534). May have a general role in telomere regulation (PMID:12676087, PMID:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PMID:12676087, PMID:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PMID:12676087, PMID:12699629). Binds to the single-stranded 5'-(GTGTGG)4GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PMID:12676087, PMID:12699629). Plays a role in nonsense-mediated mRNA decay (PMID:18974281, PMID:19060897, PMID:20930030, PMID:17053788). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PMID:18974281, PMID:19060897, PMID:20930030, PMID:17053788). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PMID:18974281, PMID:19060897, PMID:20930030, PMID:17053788). | ||
|---|---|---|---|
| Other names | Telomerase-binding protein EST1A, EC 3.1.-.-, EST1-like protein A, Ever shorter telomeres 1A, Smg-6 homolog, Telomerase subunit EST1A, hSmg5/7a, SMG6, C17orf31 EST1A KIAA0732 | ||
| Cellular localization | Cytosol, Nucleus, Telomere | ||
| Research area | Cancer | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q86US8 | ||
| Product name | Anti-SMG6 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43924 | ||
| Supplier’s Catalog No | IGX-43924 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Telomerase-binding protein EST1A protein (251-511AA) | ||
| Specificity | SMG6 antibody detects endogenous level of SMG6 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved