Anti-LRRC8E Antibody
Catalog No : IGX-43910
262.00€
188.00€
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| Description | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PMID:24790029, PMID:26824658, PMID:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PMID:24790029, PMID:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PMID:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PMID:24790029, PMID:26824658, PMID:28193731). | ||
|---|---|---|---|
| Other names | Volume-regulated anion channel subunit LRRC8E, Leucine-rich repeat-containing protein 8E, LRRC8E | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Membrane, Multi-Pass Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q6NSJ5 | ||
| Product name | Anti-LRRC8E Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43910 | ||
| Supplier’s Catalog No | IGX-43910 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Volume-regulated anion channel subunit LRRC8E protein (353-630AA) | ||
| Specificity | LRRC8E antibody detects endogenous level of LRRC8E protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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