Anti-LY6E / Lymphocyte antigen 6E Antibody
Catalog No : IGX-43877
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PMID:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PMID:28130445, PMID:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PMID:28130445, PMID:30190477). | ||
|---|---|---|---|
| Other names | Lymphocyte antigen 6E, Ly-6E, Retinoic acid-induced gene E protein, RIG-E, Stem cell antigen 2, SCA-2, Thymic shared antigen 1, TSA-1, LY6E, 9804 RIGE SCA2 TSA1 | ||
| Cellular localization | Membrane, Gpi-Anchor | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q16553 | ||
| Product name | Anti-LY6E / Lymphocyte antigen 6E Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43877 | ||
| Supplier’s Catalog No | IGX-43877 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Lymphocyte antigen 6E protein (21-101AA) | ||
| Specificity | LY6E antibody detects endogenous level of LY6E protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved