Anti-ARL6IP1 Antibody
Catalog No : IGX-43875
262.00€
188.00€
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| Description | Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport . Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PMID:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PMID:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PMID:10995579). | ||
|---|---|---|---|
| Other names | ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1, Aip-1, Apoptotic regulator in the membrane of the endoplasmic reticulum, ARL6IP1, ARL6IP ARMER KIAA0069 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Multi-Pass Membrane, Endoplasmic Reticulum, Endomembrane System, Multi-Pass Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q15041 | ||
| Product name | Anti-ARL6IP1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43875 | ||
| Supplier’s Catalog No | IGX-43875 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human ADP-ribosylation factor-like protein 6-interacting protein 1 protein (93-133AA) | ||
| Specificity | ARL6IP1 antibody detects endogenous level of ARL6IP1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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