Anti-MYL2 Antibody
Catalog No : IGX-43851
262.00€
188.00€
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| Description | Contractile protein that plays a role in heart development and function . Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force . During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly . | ||
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| Other names | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, MLC-2v, Cardiac myosin light chain 2, Myosin light chain 2, slow skeletal/ventricular muscle isoform, MLC-2s/v, Ventricular myosin light chain 2, MYL2, MLC2 | ||
| Cellular localization | A Band | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P10916 | ||
| Product name | Anti-MYL2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43851 | ||
| Supplier’s Catalog No | IGX-43851 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Myosin regulatory light chain 2, ventricular/cardiac muscle isoform protein (8-164AA) | ||
| Specificity | MYL2 antibody detects endogenous level of MYL2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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