Anti-RRAGA Antibody
Catalog No : IGX-43828
262.00€
188.00€
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| Description | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PMID:20381137, PMID:24095279, PMID:25936802). Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PMID:20381137, PMID:24095279, PMID:25936802). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PMID:20381137, PMID:25936802). Involved in the RCC1/Ran-GTPase pathway (PMID:9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PMID:8995684). (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. | ||
|---|---|---|---|
| Other names | Ras-related GTP-binding protein A, Rag A, RagA, Adenovirus E3 14.7 kDa-interacting protein 1, FIP-1, RRAGA | ||
| Cellular localization | Lysosome, Nucleus, Cytoplasm | ||
| Research area | Microbiology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q7L523 | ||
| Product name | Anti-RRAGA Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43828 | ||
| Supplier’s Catalog No | IGX-43828 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Ras-related GTP-binding protein A protein (1-247AA) | ||
| Specificity | RRAGA antibody detects endogenous level of RRAGA protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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