Anti-RAB10 Antibody
Catalog No : IGX-43765
262.00€
188.00€
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| Description | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PMID:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PMID:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PMID:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane . In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response . Plays also a specific role in asymmetric protein transport to the plasma membrane (PMID:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane . In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PMID:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation . May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PMID:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PMID:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PMID:30398148). (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. | ||
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| Other names | Ras-related protein Rab-10, RAB10 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Golgi Apparatus Membrane, Trans-Golgi Network Membrane, Endosome Membrane, Recycling Endosome Membrane, Cytoskeleton, Cilium Basal Body, Cytoplasmic Vesicle Membrane, Lipid-Anchor, , Phagosome Membrane, Perinuclear Region | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P61026 | ||
| Product name | Anti-RAB10 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43765 | ||
| Supplier’s Catalog No | IGX-43765 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Ras-related protein Rab-10 protein (1-196AA) | ||
| Specificity | RAB10 antibody detects endogenous level of RAB10 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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