Anti-MICAL2 Antibody
Catalog No : IGX-43724
262.00€
188.00€
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| Description | Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PMID:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H2O2 . Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PMID:24440334). | ||
|---|---|---|---|
| Other names | [F-actin]-monooxygenase MICAL2, EC 1.14.13.225, Molecule interacting with CasL protein 2, MICAL-2, MICAL2, KIAA0750 MICAL2PV1 MICAL2PV2 | ||
| Cellular localization | Nucleus | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O94851 | ||
| Product name | Anti-MICAL2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43724 | ||
| Supplier’s Catalog No | IGX-43724 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA) | ||
| Specificity | MICAL2 antibody detects endogenous level of MICAL2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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