Anti-H2AFB1 Antibody
Catalog No : IGX-43694
262.00€
188.00€
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| Description | Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PMID:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PMID:15257289, PMID:16287874, PMID:16957777, PMID:17591702, PMID:17726088, PMID:18329190, PMID:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PMID:15257289, PMID:16957777, PMID:17591702, PMID:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PMID:17591702, PMID:24753410). They associate with spliceosome components and are required for mRNA splicing (PMID:22795134). | ||
|---|---|---|---|
| Other names | Histone H2A-Bbd type 1, H2A Barr body-deficient, H2A.B, H2A.Bbd, H2AFB1 | ||
| Cellular localization | Chromosome, Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P0C5Y9 | ||
| Product name | Anti-H2AFB1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43694 | ||
| Supplier’s Catalog No | IGX-43694 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Histone H2A-Bbd type 1 protein (1-115AA) | ||
| Specificity | H2AFB1 antibody detects endogenous level of H2AFB1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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