Anti-GPR183 Antibody
Catalog No : IGX-43686
262.00€
188.00€
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| Description | G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes . Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PMID:21796212, PMID:22875855, PMID:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient . Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses . Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions . Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses . Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PMID:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand . Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand . Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4+ dendritic cells in bridging channels . Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PMID:25297897). Promotes osteoclast precursor migration to bone surfaces . Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PMID:21673108, PMID:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) . | ||
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| Other names | G-protein coupled receptor 183, Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, EBV-induced G-protein coupled receptor 2, hEBI2, GPR183, EBI2 | ||
| Cellular localization | Membrane, Multi-Pass Membrane | ||
| Research area | Microbiology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P32249 | ||
| Product name | Anti-GPR183 Antibody | ||
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| Catalog No | IGX-43686 | ||
| Supplier’s Catalog No | IGX-43686 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human G-protein coupled receptor 183 protein (1-31AA) | ||
| Specificity | GPR183 antibody detects endogenous level of GPR183 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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