Anti-CYP3A7 Antibody
Catalog No : IGX-43637
262.00€
188.00€
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| Description | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PMID:9555064, PMID:11093772, PMID:14559847, PMID:12865317, PMID:17178770). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PMID:9555064, PMID:11093772, PMID:14559847, PMID:12865317, PMID:17178770). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PMID:9555064, PMID:17178770). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PMID:14559847, PMID:12865317). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PMID:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PMID:9555064). | ||
|---|---|---|---|
| Other names | Cytochrome P450 3A7, EC 1.14.14.1, CYPIIIA7, Cytochrome P450-HFLA, CYP3A7 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Peripheral Membrane, Microsome Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P24462 | ||
| Product name | Anti-CYP3A7 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43637 | ||
| Supplier’s Catalog No | IGX-43637 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 3A7 protein (1-200AA) | ||
| Specificity | CYP3A7 antibody detects endogenous level of CYP3A7 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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