Anti-ATIC Antibody
Catalog No : IGX-43610
262.00€
188.00€
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| Description | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PMID:11948179, PMID:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PMID:9378707, PMID:11948179, PMID:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PMID:10985775). Also catalyzes the cyclization of FAICAR to IMP (PMID:11948179, PMID:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PMID:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PMID:25687571). | ||
|---|---|---|---|
| Other names | Bifunctional purine biosynthesis protein PURH [Cleaved into: Bifunctional purine biosynthesis protein PURH, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase, EC 2.1.2.3, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase, IMP cyclohydrolase, EC 3.5.4.10, ATIC, IMP synthase, Inosinicase,], ATIC, PURH | ||
| Cellular localization | Cytosol, Extracellular Exosome, Plasma Membrane, Membrane | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P31939 | ||
| Product name | Anti-ATIC Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43610 | ||
| Supplier’s Catalog No | IGX-43610 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Bifunctional purine biosynthesis protein PURH protein (301-592AA) | ||
| Specificity | ATIC antibody detects endogenous level of ATIC protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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