Anti-ADAM10 / CD156c Antibody
Catalog No : IGX-43599
262.00€
188.00€
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| Description | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PMID:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PMID:26686862, PMID:11786905, PMID:29224781). Contributes to the normal cleavage of the cellular prion protein (PMID:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PMID:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis . Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PMID:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PMID:19114711, PMID:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 . Enhances the cleavage of CHL1 by BACE1 . Cleaves NRCAM . Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PMID:24990881). Involved in the development and maturation of glomerular and coronary vasculature . During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions . May regulate the EFNA5-EPHA3 signaling (PMID:16239146). (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. | ||
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| Other names | Disintegrin and metalloproteinase domain-containing protein 10, ADAM 10, EC 3.4.24.81, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD antigen CD156c, ADAM10, KUZ MADM | ||
| Cellular localization | Golgi Apparatus Membrane, Single-Pass Type I Membrane, Membrane, Clathrin-Coated Vesicle, Axon, Dendrite, Adherens Junction, Cytoplasm | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O14672 | ||
| Product name | Anti-ADAM10 / CD156c Antibody | ||
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| Catalog No | IGX-43599 | ||
| Supplier’s Catalog No | IGX-43599 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA) | ||
| Specificity | ADAM10 antibody detects endogenous level of ADAM10 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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