Anti-CACNA1C / CaV1.2 Antibody
Catalog No : IGX-43595
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PMID:8392192, PMID:7737988, PMID:9087614, PMID:9013606, PMID:9607315, PMID:12176756, PMID:17071743, PMID:11741969, PMID:8099908, PMID:12181424, PMID:29078335, PMID:29742403, PMID:16299511, PMID:20953164, PMID:15454078, PMID:15863612, PMID:17224476, PMID:24728418, PMID:26253506, PMID:27218670, PMID:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm . Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PMID:15454078, PMID:15863612, PMID:17224476, PMID:24728418, PMID:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PMID:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). (Microbial infection) Acts as a receptor for Influenzavirus (PMID:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PMID:29779930). | ||
|---|---|---|---|
| Other names | Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2, CACNA1C, CACH2 CACN2 CACNL1A1 CCHL1A1 | ||
| Cellular localization | Membrane, Multi-Pass Membrane, Sarcolemma, Postsynaptic Density Membrane, T-Tubule, Perikaryon, Dendrite | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13936 | ||
| Product name | Anti-CACNA1C / CaV1.2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43595 | ||
| Supplier’s Catalog No | IGX-43595 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C protein (1755-1971AA) | ||
| Specificity | CACNA1C antibody detects endogenous level of CACNA1C protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved