Anti-ATG16L1 Antibody
Catalog No : IGX-43583
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PMID:24553140, PMID:23376921, PMID:24954904, PMID:27273576, PMID:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PMID:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PMID:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PMID:20637199). Plays a role in regulating morphology and function of Paneth cell (PMID:18849966). | ||
|---|---|---|---|
| Other names | Autophagy-related protein 16-1, APG16-like 1, ATG16L1, APG16L | ||
| Cellular localization | Cytoplasm, Preautophagosomal Structure Membrane, Peripheral Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q676U5 | ||
| Product name | Anti-ATG16L1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43583 | ||
| Supplier’s Catalog No | IGX-43583 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC, IF | ||
| Recommended dilutions | IHC: 1:20-1:200, IF: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Autophagy-related protein 16-1 protein (1-607AA) | ||
| Specificity | ATG16L1 antibody detects endogenous level of ATG16L1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved