Anti-TENM1 Antibody
Catalog No : IGX-43535
262.00€
188.00€
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| Description | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer . Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking . Ten-1 intracellular domain: Induces gene transcription activation. | ||
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| Other names | Teneurin-1, Ten-1, Protein Odd Oz/ten-m homolog 1, Tenascin-M1, Ten-m1, Teneurin transmembrane protein 1, [Cleaved into: Ten-1 intracellular domain, IDten-1, Ten-1 ICD, Teneurin C-terminal-associated peptide, TCPA-1, Ten-1 extracellular domain, Ten-1 ECD,], TENM1, ODZ1 TNM1 | ||
| Cellular localization | Membrane, Single-Pass Membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Nucleus Speckle, Nucleus Matrix | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UKZ4 | ||
| Product name | Anti-TENM1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43535 | ||
| Supplier’s Catalog No | IGX-43535 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Teneurin-1 protein (1-241AA) | ||
| Specificity | TENM1 antibody detects endogenous level of TENM1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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