Anti-CPNE1 Antibody
Catalog No : IGX-43532
262.00€
188.00€
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| Description | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PMID:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PMID:14674885). Exhibits calcium-dependent phospholipid binding properties (PMID:9430674, PMID:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PMID:23263657, PMID:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PMID:12522145). May function in membrane trafficking (PMID:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PMID:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PMID:18212740). | ||
|---|---|---|---|
| Other names | Copine-1, Chromobindin 17, Copine I, CPNE1, CPN1 | ||
| Cellular localization | Membrane, Nucleus, Cytoplasm | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q99829 | ||
| Product name | Anti-CPNE1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43532 | ||
| Supplier’s Catalog No | IGX-43532 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Copine-1 protein (326-537AA) | ||
| Specificity | CPNE1 antibody detects endogenous level of CPNE1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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