Anti-BOK Antibody
Catalog No : IGX-43444
262.00€
188.00€
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| Description | Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PMID:27076518, PMID:15102863, PMID:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PMID:27076518, PMID:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response . Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PMID:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PMID:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PMID:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation . In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PMID:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PMID:24113155). Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. | ||
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| Other names | Bcl-2-related ovarian killer protein, hBOK, Bcl 2-L-9, BOK, BCL2L9 | ||
| Cellular localization | Golgi Apparatus, Cis-Golgi Network Membrane, Trans-Golgi Network Membrane, Endoplasmic Reticulum Membrane, Single-Pass Membrane, Endoplasmic Reticulum, Mitochondrion, Mitochondrion Membrane, Mitochondrion Outer Membrane, Early Endosome Membrane, Recycling Endosome Membrane, Nucleus, Nucleus Outer Membrane, Cytoplasm, Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UMX3 | ||
| Product name | Anti-BOK Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43444 | ||
| Supplier’s Catalog No | IGX-43444 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Bcl-2-related ovarian killer protein (15-103AA) | ||
| Specificity | BOK antibody detects endogenous level of BOK protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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