Anti-CYP1A2 Antibody
Catalog No : IGX-43391
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| Description | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PMID:9435160, PMID:10681376, PMID:11555828, PMID:12865317, PMID:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PMID:9435160, PMID:10681376, PMID:11555828, PMID:12865317, PMID:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PMID:11555828, PMID:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PMID:11555828, PMID:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PMID:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PMID:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PMID:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PMID:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PMID:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PMID:14725854). Metabolizes caffeine via N3-demethylation (Probable). | ||
|---|---|---|---|
| Other names | Cytochrome P450 1A2, EC 1.14.14.1, CYPIA2, Cholesterol 25-hydroxylase, Cytochrome P,3,450, Cytochrome P450 4, Cytochrome P450-P3, CYP1A2 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Peripheral Membrane, Microsome Membrane, Peripheral Membrane | ||
| Research area | Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P05177 | ||
| Product name | Anti-CYP1A2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43391 | ||
| Supplier’s Catalog No | IGX-43391 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 1A2 protein (268-445AA) | ||
| Specificity | CYP1A2 antibody detects endogenous level of CYP1A2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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